Phase ONE is a non-profit organization dedicated to supporting Phase I clinical research and treatment programs for patients with cancer. Founded by Stacy and Alberto Valner, with a group of friends, all couples with young children who either themselves or a close family member had been affected by a diagnosis of cancer.

Once a new idea or novel drug is identified in the laboratory, the FDA requires three levels of clinical testing prior to the approval of that drug for widespread use. These studies are usually referred to as trials in Phase I, II, or III. The focus of a Phase I trial is to determine the appropriate dose and schedule of a given drug and its side effects. Patients enrolled usually have advanced cancers, which have progressed through standard therapy or for which standard therapy does not exist. Sometimes these patients have been through "everything" and still function extremely well. The Phase II trial applies the Phase I information on dose and schedule and tries to get a hint of efficacy. The Phase III trial, is the final set of studies, which usually involves hundreds, if not thousands of patients worldwide. Clinical trials are the only way to understand what are the best and safest therapies available to patients with any disease.

With your support Phase ONE hopes that its efforts to fund Phase I trials and research will help in the fight against cancer, by finding treatments that will transform what might be a terminal illness into one where patients can live a full and productive life. Phase ONE is determined to:

• Offer hope to the patient today that has been told there is nothing left.
• Allow patients in our community the access to whatever types of therapy may be available around the world.
• Make the time a patient goes through treatment easier by improving patient care.
• Support research that takes advantage of the vast amount of new information about what causes cancers.
• Lay the groundwork for larger scale multi-center research that can set new standards of oncology care.
• Make sure that those diagnosed with cancer in the future will have even safer and more effective treatments to live long lives with their disease too.

Thanks to all for their support!